王玉娥

系 所：预防兽医系

职 称：教授

电子邮箱： vetyuewang@swu.edu.cn

讲授课程：本科课程：《兽医微生物学》、《兽医免疫学》等。

       研究生课程：《兽医微生物学》、《预防兽医学seminar》等。

个人简介

教育经历

1993.9–1997.7 河北农业大学畜牧兽医学院兽医专业本科，农学学士

1997.9–2000.6 河北农业大学畜牧兽医学院兽医微生物与免疫学专业，农学硕士

2000.9–2003.6 中国农业大学预防兽医学专业，理学博士

工作经历

2003.8－2004.12，中国疾病预防控制中心病毒病预防控制所从事科研工作；

2005.1－2012.7，美国明尼苏达大学欧洲杯买球正规平台从事科研工作；

2012.7－2022.7，中国农业科学院哈尔滨兽医研究所从事教学、科研工作。担任实验动物与比较医学创新团队执行首席。

2022.8－至今，欧洲杯买球正规平台从事教学、科研工作。
 研究领域

主要从事猪繁殖与呼吸综合征、猪病毒性腹泻、猪圆环病毒病等猪病毒性病原的感染与致病、免疫机制与防控技术研究。

科研项目

1. 猪病毒病致病机制及抗病毒感染免疫研究，欧洲杯买球正规平台引进人才项目，2022/09-2027/08，在研，主持；

2. 生猪腹泻病防控技术与产品研发，国家生猪技术创新中心先导科技项目，2023/01-2025/12，在研，参与；

3. 高等级农业实验动物猪培育、质量控制及检测技术研究，黑龙江省重点研发计划，GZ20210010，2021/10-2023/9，在研，主持；

4. 基于肠道菌群-肠肺轴探究乳酸菌协助机体抵抗流感病毒感染的作用机制的研究，(2) 国家自然基金面上项目， 2020/01-2024/12，32072898，在研，项目执行人；

5. 实验动物健康管理技术支持与检测服务，横向课题，202100301，2021/03-2022/12，在研，主持；

6. 嗜中性粒细胞在猪流行性腹泻病毒感染中的作用及机制研究，国家自然基金面上项目，31572497，2016/01-2019/12，结题，主持；

7. 紧密连接蛋白在猪流行性腹泻病毒感染中的作用及机制研究，黑龙江省杰出青年基金，JC2016005，2016/07-2019/06，结题，主持；

8. 金属蛋白酶ADAM17对猪繁殖与呼吸综合征病毒感染的抑制作用及机制研究，国家自然基金面上项目，31372416，2014/01-2017/12，结题，主持；

9. 猪流行性腹泻病毒诱导细胞凋亡机制的研究，黑龙江省自然科学基金，LC201418，2014/07-2017/06，结题，主持；

10. Parallel monitoring of porcine diseases of economic importance in the United States and China，美国农业部合作项目，3625-32000-108-17S，2013/09- 2014/09，结题，主持

代表成果

代表著作

1. 参译《猪病学》，辽宁科学技术出版社，2021年12月

2. 参编《实验动物管理与操作》，中国农业科学技术出版社，2021年11月

3. 参编 《兽医微生物学》，中国海洋大学出版社出版，2013年6月

代表论文

1. Zhang Lin#, Pan Yu#, Xu Yunfei, Zhang Wenli, Ma Wenjie, Ibrahim Yassein, Werid Mamu, Zhang He, Xia Changyou, Wei Ping, Chen Hongyan*, Wang Yue*. Paraoxonase-1 facilitates PRRSV replication by interacting with viral nonstructural protein-9 and inhibiting type I interferon pathway. Viruses. 2022, 14, 1203. https://doi.org/10.3390/v14061203

2. Wang Dongfang, Huo Hong, Werid Mamu, Ibrahim Yassein, Tang Lijie*, Wang Yue*, Chen Hongyan*. TBK1 mediates innate antiviral immune response against duck enteritis virus. Viruses. 2022.14(5):1008. doi:10.3390/v14051008

3. Werid Mamu#, Ibrahim Yassein#, Chen Hongyan, Fu Lizhi*, Wang Yue*. Molecular detection and genetic characterization of potential zoonotic swine enteric viruses in Northern China. Pathogens. 2022. 11(4):417. doi:10.3390/ pathogens11040417

4. Werid Mamu#, Zhang He#, Ibrahim Yassein, Pan Yu, Zhang Lin, Xu Yunfei, Zhang Wenli, Wang Wei, Chen Hongyan, Fu Lizhi*, Wang Yue*. Development of a multiplex RT-PCR assay for simultaneous detection of four potential zoonotic swine RNA viruses. Veterinary Sciences. 2022. 9(4):176. doi:10.3390/vetsci9040176

5. Ibrahim Yassein, Zhang Wenli, Werid Mamu, Zhang He, Pan Yu, Zhang Lin, Xu Yunfei, Li Chanwen, Chen Hongyan, Wang Yue*. Characterization of parainfluenza virus 5 from diarrheic piglet highlights its zoonotic potential. Transboundary and Emerging Diseases. 2022. doi:10.1111/tbed.14482

6. Ibrahim Yassein, Werid Mamu, Zhang He, Fu Lizhi, Wang Wei, Chen Hongyan, Wang Yue*. Potential zoonotic swine enteric viruses: The risk ignored for public health. Virus Research. 2022. 315:198767. doi:10.1016/j.virusres.2022.198767

7. Ibrahim Yassein#, Zhang Wenli#, Werid Mamu, Zhang He, Feng Yawen, Pan Yu, Zhang Lin, Li Changwen, Lin Huan, Chen Hongyan, Wang Yue*. Isolation, characterization, and molecular detection of porcine sapelovirus. Viruses. 2022. 14(2):349. doi: 10.3390/v14020349

8. Zhang He, Ma Wenjie, Sun Zhi, Zhu Changkang, Werid Mamu, Ibrahim Yassein, Zhang Wenli, Pan Yu, Shi Dongfang, Chen Hongyan*, Wang Yue*. Abundance of Lactobacillus in porcine gut microbiota is closely related to immune response following PRRSV immunization. Veterinary Microbiology. 2021. 259: 109134

9. Zhang Lin#, Zhang Lu#, Pan Yu, Gao Junxin, Xu Yunfei, Li Xi, Tian Zhijun, Chen Hongyan, Wang Yue*. Downregulation of miR-218 by porcine reproductive and respiratory syndrome virus facilitates viral replication via inhibition of type I interferon. Journal of Biological Chemistry. 2021. DOI: 10.1016/j.jbc.2021.100683

10. Gao Junxin, Pan Yu, Xu Yunfei, Zhang Wenli, Zhang Lin, Li Xi, Tian Zhixi, Chen Hongyan, Wang Yue*. Unveiling the long non-coding RNA profile of porcine reproductive and respiratory syndrome virus-infected porcine alveolar macrophages. BMC Genomics. 2021. 22:177

11. Xu Jiayu#, Zhang Lu#, Xu Yunfei, Zhang He, Gao Junxin, Wang Qian, Tian Zhijun, Xuan Lv, Chen Hongyan*, Wang Yue*. PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production. Viruses. 2019. 11(10): 948

12. Yang Lijun#, Xu Jiayu#, Guo Longjun, Guo Taijie, Zhang Lu, Feng Li, Chen Hongyan, Wang Yue*. Porcine Epidemic Diarrhea Virus-Induced Epidermal Growth Factor Receptor Activation Impairs the Antiviral Activity of Type I Interferon. Journal of Virology. 2018 Mar 28. 92(8). Pii: e02095-17

13. Zhang Jian#, Guo Longjun#, Yang Lijun, Xu Jiayu, Zhang Lu, Feng Li, Chen Hongyan, Wang Yue*. Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. Virology. 2018. Apr. 517: 24-29

14. Luo Xiaolei#, Guo Longjun#, Zhang Jian, Xu Yunfei, Gu Weihong, Feng Li, Wang Yue*. Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor. Journal of Virology. 2017, 91(10). pii: e00202-17

15. Zhang Jian, Guo Longjun, Xu Yunfei, Yang Lijun, Shi Hongyan, Feng Li, Wang Yue*. Characterization of Porcine Epidemic Diarrhea Virus Infectivity in Human Embryonic Kidney Cells. Archives of Virology. 2017, 162(8):2415-2419

16. Guo Longjun, Luo Xiaolei, Li Ren, Xu Yunfei, Zhang Jian, Ge Jinying, Bu Zhigao, Feng Li, Wang Yue*. Porcine epidemic diarrhea virus infection inhibits interferon signaling by targeted degradation of STAT1. Journal of Virology. 2016, 90(18): 8281-92

17. Guo Longjun#, Yu Haidong#, Gu Weihong, Luo Xiaolei, Li Ren, Zhang Jian, Xu Yunfei, Yang Lijun, Shen Nan, Feng Li, Wang Yue*. Autophagy negatively regulates transmissible gastroenteritis virus replication. Scientific Reports. 2016, 6:23864

18. Li Ren, Guo Longjun, Gu Weihong, Luo Xiaolei, Zhang Jian, Xu Yunfei, Tian Zhijun, Feng Li, Wang Yue*. Production of Porcine TNFa by ADAM17- mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Immunologic Research. 2016, 64(3): 711-20

19. Gu Weihong#, Guo Longjun#, Li Ren, Niu Junwei, Luo Xiaolei, Zhang Jian, Xu Yunfei, Tian Zhijun, Feng Li, Wang Yue*. Elevated plasma soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding. Journal of General Virology. 2016, 97(3):632-8

20. Gu Weihong, Guo Longjun, Yu Haidong, Niu Junwei, Huang Mingming, Luo Xiaolei, Li Ren, Tian Zhijun, Feng Li, Wang Yue*. Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection. Journal of General Virology. 2015, 96(7): 1712-1722

21. Guo Longjun, Niu Jiuwei, Yu Haidong, Gu Weihong, Huang Mingming, Li Ren, Luo Xiaolei, Tian Zhijun, Feng Li, Wang Yue*. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. Journal of Virology. 2014, 88(18): 10448-58

22. Lin Z, Wang J, Zhao S, Li Y, Zhang Y, Wang Yue, Yan Y, Cheng Y*, Sun J. *. Goose IRF7 is involved in antivirus innate immunity by mediating IFN activation. Developmental & Comparative Immunology. 2022, 133:104435

23. Zhang Y, Wu D, Fan Z, Li J, Gao L, Wang Yue, Wang L. Microcystin-LR induces ferroptosis in intestine of common carp (Cyprinus carpio). Ecotoxicol Environ Saf. 2021, 223:112610

24. Huo Hong, Wang Yue, Wang Dongfang, Wang Yiping, Chen Xiaohan, Zhao Lili, Chen Hongyan. Duck RIG-I restricts duck enteritis virus infection. Veterinary Microbiology. 2019, 230:78-85

25. Zhang Yuanyuan, Lu Taofeng, Wang Yue, Diao Chenxi, Zhou Yan, Zhao Lili, Chen Hongyan. J Agri Food Chem. 2018, 66:12102-12110

标准

实验动物 猪寄生虫学等级及监测（DB23/T 2057.9—2017）. 制定人：王玉娥、贾洪林、高彩霞、宋莹、宋新刚、邬立权、孙东波、何春波、高利

主要奖励

2019-2020年，中国农业科学院教学名师

2017年，黑龙江省自然科学一等奖

2017年，黑龙江省畜牧科技一等奖

2017年，国家科学技术进步二等奖